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KMID : 0043320120350061009
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Archives of Pharmacal Research
2012 Volume.35 No. 6 p.1009 ~ p.1013
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Evaluation of some classical hydrazones of ketones and 1,2-diketones as antileishmanial, antibacterial and antifungal agents
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Al kahraman Yasser M. S. A.
Yasinzai Masoom
Singh Girija S.
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Abstract
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The paper describes the synthesis and antimicrobial (antileishmanial, antibacterial and antifungal) activity of some classical hydrazones of benzophenones and of 1,2-diketones. N-(Diaryl) acyl derivatives of these hydrazones have also been synthesized and evaluated. 4,4,-Demthoxybenzil monohydrazone and 4,4′-dimethoxybenzophenone hydrazone showed significant antileishmanial activity. The effect of substituents on the bioactivity is discussed.
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KEYWORD
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Hydrazones, N-(diaryl)acyl hydrazones, Antileishmanial, Antibacterial, Antifungal
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